Damgaard 2010.
Methods | Participants were randomised using sealed, opaque, and numbered envelopes to one of two groups: a cell salvage group and a control group. Allocation concealment was achieved during the randomisation process. |
Participants | 30 participants aged over 18, undergoing CABG, who provided informed consent were randomised to one of the following groups using the methodology described above: Cell saver: N = 15. Median (IQR) age 66 (53 to 72). M:F 12:3 Control: N = 14. Median (IQR) age 68 (65 to 74). M:F 11:3 |
Interventions |
Cell saver: in the cell salvage group, all suctioned blood was processed using an Autolog Cell Saver (Medtronic, Minneapolis, MN) prior to re‐transfusion. Residual blood in the cardiopulmonary bypass machine was processed prior to re‐transfusion; however, the cardiotomy suction blood was not processed. Autotransfusion was performed immediately postoperatively. Control: in the control group, all suctioned blood from before and after the start of CPB was collected using the waste suction and discarded. Cardiotomy suction was used during CPB. It is unclear how blood remaining in the bypass machine at the end of the procedure was handled. No postoperative autotransfusion of drain blood was performed in either group. |
Outcomes | Outcomes reported: patient plasma concentration of interleukin 6 (IL‐6) at 6, 24 and 72 hours after the end of CPB; plasma concentrations of Il‐1B, IL‐8, IL‐10, IL‐12, tumour necrosis factor alpha (TNF‐a), TNF‐R1, sTNF‐RII and procalcitonin at 6, 24 and 72 hours after the end of CPB; bleeding; allogeneic transfusions; cell saver effectiveness regarding inflammatory marker reduction; complications |
Notes |
Transfusion protocol: a haemoglobin concentration of < 6 mmol/L or a haematocrit of < 25% triggered an allogeneic transfusion. Prospective registration status: the study was not prospectively registered on a trials registry (NCT00159926). Ethical approval: the study was approved by the regional research ethics committee to Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK‐2100 Copenhagen, Denmark. Language: the study was published in English. Reason for awaiting classification status: it is unclear how blood remaining in the cardiopulmonary bypass circuit was handled. |