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Patient 25 (a) Primary giant cell tumor of bone before denosumab therapy (b) Osteosarcoma after denosumab therapy (c) Osteosarcoma with blastic cells (d) with immature osteoid tissue (e) chondroblastic cells. Scalebar in (a,b), image in the back: 200 µm; in (a,b), small image in front and (c–e): 100 µm.
