Table 1.
WHO classification of fibroblastic/myofibroblastic and some representative immunomarkers.
| Type of Tumor | Representative Immunomarkers |
|---|---|
| Nodular fasciitis | CD34 (+), SMA (+), Desmin (−), S100 (−), ALK-1 (−), Ki-67(+) |
| Proliferative fasciitis | SMA (+), Desmin (−), CD34 (+), S100 (−), ALK-1 (−), Ki-67 (+) |
| Proliferative myositis | SMA (+), CD34 (+), Desmin (−), S100 (−), ALK-1 (−), Ki-67 (+) |
| Myositis ossificans | SMA (+), Desmin (−), CD34 (−), S100(−), ALK-1 (−), Ki-67 (−) |
| Ischaemic fasciitis | SMA (+), Desmin (−), CD34 (+), S100(−), ALK-1 (−), Ki-67 (+) |
| Elastofibroma | SMA (+), Desmin (−), CD34 (−), S100 (−), ALK-1 (−), Ki-67 (−) |
| Fibrous hamartoma of infancy | SMA (+), Desmin (−), CD34 (+), S100(−), ALK-1 (−), Ki-67 (+) |
| Myofibroma/Myofibromatosis | SMA (+), Desmin (−), CD34 (−), S100 (−), ALK-1 (−), Ki-67 (+) |
| Fibromatosis colli | SMA (+), Desmin (−), CD34 (−), S100 (−), ALK-1 (−), Ki-67 (−) |
| Juvenile hyaline fibromatosis | Vimentin (+), CD34 (−), CD68 (−), SMA (−),S 100(−), Factor XIIIa (−) |
| Inclusion body fibromatosis | Vimentin (+), CD34 (−), CD68 (−), SMA (−), S100 (−), Desmin (−) |
| Fibroma of tendon sheath | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
| Desmoplastic fibroblastoma | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100(−), CD68 (−) |
| Mammary-type myofibroblastoma | Vimentin (+), CD34 (−), Desmin (−), SMA (+), S100 (−), CD68 (−) |
| Calcifying aponeurotic fibroma | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
| Angiomyofibroblastoma | Vimentin (+), CD34 (−), Desmin (−), SMA (+), S100 (−), CD68 (−) |
| Cellular angiofibroma | Vimentin (+), CD34 (+), Desmin (−), SMA (−), S100 (−), CD68 (−) |
| Nuchal-type fibroma | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
| Gardner fibroma | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
| Calcifying fibrous tumor | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
| Giant cell angiofibroma | Vimentin (+), CD34 (−), Desmin (−), SMA (+), S100 (−), CD68 (−) |
| Superficial fibromatoses (palmar/plantar) | SMA (+), CD34 (−), Desmin (−), S100 (−), Beta-catenin(CTNNB1) (+) |
| Desmoid-type fibromatoses | SMA (+), CD34 (−), Desmin (−), S100 (−), Beta-catenin(CTNNB1) (+) |
| Lipofibromatosis | CD34 (+), SMA (+), Desmin (−), S100 (−), Beta-catenin(CTNNB1) (−) |
| Solitary fibrous tumor | CD34 (+), CD99 (+), Bcl-2 (+), CD31 (−), S100 (−), Desmin (−) |
| Inflammatory myofibroblastic tumor | ALK [partly(+)], SMA (+), CD34 (+), Desmin (−), CD117 (−), S100 (−) |
| Low grade myofibroblastic sarcoma | SMA (+), Desmin (−), CD34 (−), CD117 (−), ALK (−), S100 (−) |
| Myxoinflammatory | CD68 (+), CD163 (+), SMA (+), Desmin (−), CD34 (−), S100 (−) |
| Infantile fibrosarcoma | SMA (+), Desmin (−), CD34 (−), CD99 (−), ALK (−), S100 (−) |
| Adult fibrosarcoma | SMA (+), CD34 (−), Desmin (−), S100 (−), EMA (−), CD99 (−) |
| Myxofibrosarcoma | CD34 (−), SMA (−), Desmin (−), S100 (−), EMA (−), CD99 (−) |
| Low grade fibromyxoid sarcoma | CD34 (−), SMA (−), Desmin (−), S100 (−), EMA (−), MUC4 (+) |
| Sclerosing epithelioid fibrasarcoma | CD34 (−), SMA (−), Desmin (−), S100 (−), EMA (−), INI1(SMARCB1):(+) |
Ki-67: Ki-67 Antigen; Factor XIIIa: Factor XIIIa (F13A1); Beta-catenin (CTNNB1): Beta-Catenin; INI1 (SMARCB1): SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily B member 1; Bcl-2: B-Cell Lymphoma 2.