. 2023 Aug 25;12(17):2144. doi: 10.3390/cells12172144

Table 1.

Extracellular classification based on biogenesis, concept, and size.

EV Category	Name	EV Class	Size (nm)	Markers	Biogenesis
Exosomes	Classical	Small	30–200	CD63⁺/CD9⁺/CD81⁺	MVE
Exosomes	Non-classical	Small	30–200	CD63⁺/CD9⁺/CD81⁻	MVE
Microvesicle	Classical	Large	150–1000	Annexin A1, ARF6	PMS
	Oncosomes	Large	1000–10,000	Annexin A1, ARF6	PMS
	ARMM	Small	40–100	ARRDC1, TSG101	PMS
Apoptotic	Apoptotic body	Large	1000–5000	Annexin V, PS	Apoptosis
Apoptotic	Apoptotic vesicle	Small to large	100–1000	Annexin V, P5	Apoptosis
Autophagic	Autophagic EV	Small to large	40–1000	LC3B-PE, p62, dsDNA/histones	Amphisome
Stressed (Stressome)	Stressed EV	Small to large	40–1000	HSP90, HSPs	PMS
Stressed (Stressome)	Damaged EV	Small to large	40–1000	CD63⁺/CD9⁺/CD81⁺	PMS
Matrix vesicles	Matrix vesicles	Small to large	40–1000	Fibronectin, Proteoglycan	Matrix binding release

MVE—multivesicular endosome; ARMM—arrestin-domain-containing protein 1 (ARRDC1)-mediated microvesicle; PMS—plasma membrane shedding; Amphisome—Autophagosome-endosome fusion. Table adapted from Sheta et al. [104].