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. 2023 Sep 1;12(17):2191. doi: 10.3390/cells12172191

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Specific analysis of CRP. CRP was analyzed with PRM-MS (top row) and ELISA (bottom row) in both platelets (a,d) and plasma (b,e). A similar pattern was observed with both methods. ICU patients showed the highest CRP level, which was significantly increased compared with the control group. Survivors (ICU B) tended to have marginally lower CRP levels than non-survivors (ICU A). NW tended to present lower CRP levels than ICU. A similar pattern was observed in plasma samples. A correlation between platelet and plasma levels could be demonstrated by both PRM-MS (p < 0.0001) (c) and ELISA (p < 0.0001) (f). Platelet and plasma readings are presented as boxplots. Data were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison. The correlation was determined according to Spearman. ICU: intensive care unit (ICU A: non-survivors, ICU B: survivors, ICU N: unknown); NW: normal ward.