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. 2023 Sep 1;12(17):2191. doi: 10.3390/cells12172191

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Figure A3 — The top 20 enriched biological processes across, colored by p-values (the darker the color, the more statistically significant). (a) 186 differently abundant PGs (p < 0.05) from the comparison of controls vs. NW. Changes were mainly associated with cell adhesion and protein folding and platelet activation, signaling, and aggregation. (b) A total of 122 differently abundant PGs (p < 0.05) from the comparison of ICU (A+B+N) vs. NW. This comparison showed the most significant association with protein folding and cell adhesion and platelet activation, signaling, and aggregation. (c) A total of 116 differently abundant PGs (p < 0.05) from the comparison of ICU B vs. NW. Over time, the survivors showed changes associated with platelet degranulation and protein folding. ICU: intensive care unit (ICU A: non-survivors, ICU B: survivors, ICU N: unknown); NW: normal ward.