Table 1.
Patients’ baseline characteristics. COPD: chronic obstructive pulmonary disease; CRP: C-reactive protein; ECMO: extracorporeal membrane oxygenation; ICU: intensive care unit (ICU A: non-survivors, ICU B: survivors, ICU N: unknown); IL-6: interleukin 6; INR: international normalized ratio; NW: normal ward; PTT: partial thromboplastin time.
| ICU (A+B+N) | NW | Control | |
|---|---|---|---|
| n | 19 | 5 | 16 |
| age, median (range) [a] | 62 (46–81) | 61 (46–69) | 61.5 (48–70) |
| male, n (%) | 19 (100.0) | 5 (100.0) | 16 (100.0) |
| Platelet count on sampling, median (range) (109/L) | 164 (25–309) | 243 (213–253) | 285.5 (179–414) |
| immature platelet fraction on sampling, median (range) (%) | 6.1 (2.7–11.5) | 2.0 (0.9–4.7) | 3.4 (1.6–14.3) |
| Hospitalization | |||
| total stay, median (range) (d) | 30 (4–113) | 51 (35–78) | |
| ICU, median (range) (d) | 24 (4–113) | 34 (24–63) | NA |
| NW, median (range) (d) | 12.5 (6–26) | 15 (6–26) | |
| Outcome at discharge | |||
| deceased, n (%) | 11 (57.9) | 0 (0.0) | |
| improved, n(%) | 6 (31.6) | 5 (100.0) | NA |
| unknown, n(%) | 2 (10.5) | 0 (0.0) | |
| Comorbidities | |||
| adipositas, n (%) | 7 (36.8) | 2 (40.0) | |
| hypertension, n (%) | 12 (63.2) | 3 (60.0) | |
| hyperlipoproteinemia, n (%) | 4 (21.1) | 1 (20.0) | |
| diabetes mellitus type II, n (%) | 7 (36.8) | 2 (40.0) | NA |
| cardiac disease, n (%) | 11 (57.9) | 3 (60.0) | |
| COPD, n (%) | 2 (10.5) | 0 (0.0) | |
| renal insufficiency, n (%) | 5 (26.3) | 1 (20.0) | |
| Treatment | |||
| invasive mechanical ventilation, n (%) | 18 (94.7) | 5 (100.0) | |
| ECMO, n (%) | 13 (68.4) | 2 (40.0) | |
| ECMO duration, mean (d) | 17.5 | 9.4 | |
| convalescent plasma, n (%) | 7 (36.8) | 2 (40.0) | NA |
| platelet concentrate, n (%) | 14 (73.7) | 1 (20.0) | |
| platelet concentrate number, mean | 4.5 | 0.4 | |
| dexamethasone, n (%) | 11 (57.9) | 0 (0.0) | |
| Laboratory findings on admission | |||
| leukocytes, median (range) (109/L) | 12.3 (4.1–46.0) | 10.1 (4.1–18.9) | |
| erythrocytes, median (range) (1012/L) | 3.6 (3.0–5.0) | 4.34 (3.73–5.04) | |
| platelets, median (range) (109/L) | 210 (73–770) | 188 (126–331) | |
| CRP, median (range) (mg/dL) | 19.0 (4.7–53.0) | 14.0 (9.2–26.0) | |
| IL-6, median (range) (pg/mL) | 116 (26–938) | 88 (46–143) | NA |
| fibrinogen, median (range) (mg/dL) | 624 (286–900) | 543 (286–624) | |
| d-dimer, median (range) (mg/L) | 3.5 (0.6–35.2) | 2.3 (0.6–35.2) | |
| PTT, median (range) (s) | 29 (23–200) | 25 (23–46) | |
| INR, median (range) | 1.1 (1.0–1.9) | 1 (1.0–1.9) |