Table 2.
Multivariable analysis for OS (A) and PFS (B).
| Factor | HR (95% CI) | p-Value |
|---|---|---|
| (A). Multivariable Analysis for OS | ||
| LDH elevated ≥ 2x ULN at time of infusion | 7.40 (1.56–35.00) | 0.0116 * |
| No response to bridging therapy | 3.73 (0.75–18.45) | 0.1072 |
| Hemoglobin < 6 mmol/L at time of infusion | 3.18 (1.16–8.75) | 0.0247 * |
| LDH elevated 1 − 2x ULN at time of infusion | 2.68 (0.98–7.36) | 0.0553 |
| Response to bridging therapy | 2.35 (0.43–12.88) | 0.3240 |
| IPI score high intermediate and high risk (≥3) | 2.35 (1.06–5.2) | 0.0354 * |
| Male sex | 2.33 (0.82–6.62) | 0.1125 |
| Platelets < 75 × 109/L at time of infusion | 1.92 (0.72–5.15) | 0.1935 |
| ECOG performance status ≥ 2 at time of infusion | 1.44 (0.24–8.56) | 0.6899 |
| ECOG performance status = 1 at time of infusion | 1.07 (0.47–2.47) | 0.8661 |
| No CR to first-line treatment (primary refractory disease) | 1.07 (0.43–2.65) | 0.8864 |
| LDH elevated 1 − 2x ULN at screening | 0.91 (0.37–2.24) | 0.8290 |
| CRP > 50 mg/L at time of infusion | 0.82 (0.27–2.49) | 0.7230 |
| Ferritin > 1000 µg/L at time of infusion | 0.53 (0.21–1.35) | 0.1856 |
| LDH elevated ≥ 2x ULN at screening | 0.44 (0.10–1.85) | 0.2627 |
| (B). Multivariable analysis for PFS | ||
| No response to bridging therapy | 2.68 (1.00–7.17) | 0.0497 * |
| LDH elevated ≥ 2x ULN at time of infusion | 2.31 (0.71–7.53) | 0.1630 |
| IPI score high intermediate and high risk (≥3) | 2.28 (1.20–4.33) | 0.0123 * |
| Hemoglobin < 6 mmol/L at time of infusion | 2.27 (1.04–4.95) | 0.0392 * |
| LDH elevated 1 − 2x ULN at time of infusion | 1.75 (0.87–3.55) | 0.1185 |
| Response to bridging therapy | 1.24 (0.44–3.49) | 0.6876 |
| Platelets < 75 × 109/L at time of infusion | 1.09 (0.52–2.28) | 0.8101 |
| CRP > 50 mg/L at time of infusion | 1.06 (0.51–2.19) | 0.8756 |
| Ferritin > 1000 µg/L at time of infusion | 0.79 (0.40–1.56) | 0.4957 |
| LDH elevated 1 − 2x ULN at screening | 0.73 (0.36–1.49) | 0.3861 |
| LDH elevated ≥ 2x ULN at screening | 0.64 (0.21–1.89) | 0.4160 |
Abbreviations: CI: confidence interval, CR: complete response, ECOG: Eastern Cooperative Oncology Group, HR: hazard ratio, IPI: international prognostic index, OS: overall survival, PFS: progression-free survival. * Significant association at a p-value of ≤0.05 considered statistically significant.