Figure 1.

Molecular mechanism of mitochondrial dynamic and its relevant to age-related muscle atrophy. Mitochondria in skeletal muscle form a dynamic network and can be reshaped by fusion and fission process. Relationship between mitochondria dynamic and age-related muscle fiber atrophy is highlighted in this figure. Mitochondria in oxidative fiber is more filamentous which prevent the oxidative fiber from age-related loss of mitochondria and thus preserve the oxidative fiber with age. On the other hand, mitochondria in glycolytic fiber is more fragmented which cause glycolytic fiber to be affected more during aging.