Figure 3.

Depression interacted with lipopolysaccharide-binding protein (LBP) to predict cognitive function. Depressed women with greater intestinal permeability reported poorer focus and memory and were slower to complete Trail Making Test A. The combination of depression and heightened intestinal permeability also predicted Hopkins total recall, but in the opposite direction as expected, such that depressed women recalled fewer words than non-depressed women only if they had low and average, but not high, levels of LBP.