Table 5.
Inflammatory markers and depressive symptoms for included subjects across all study visits used in at least one analysis model.
| Study 1 (n = 435 Visits) | Study 2 (n = 266 Visits) | Study 3 (n = 162 Visits) | Study 4 (n = 252 Visits) | Total (n = 1116 Visits) | ||
|---|---|---|---|---|---|---|
| IL-6 | ||||||
| M(SD) | 2.2 (2.3) | 2.3 (2.2) | 2.8 (6.3) | 2.9 (2.4) | 2.5 (3.2) | |
| [min, max] | [0.15, 21.8] | [0.15, 15.1] | [0.44, 78.4] | [0.06, 14.0] | [0.06, 78.4] | |
| TNF-α | ||||||
| M(SD) | 7.4 (3.8) | 7.1 (3.2) | 2.3 (0.6) | 2.4 (0.7) | 5.5 (3.7) | |
| [min, max] | [1.3, 28.4] | [2.1, 27.0] | [1.2, 4.5] | [1.0, 4.7] | [1.0, 28.4] | |
| CRP | ||||||
| M(SD) | 3.0 (5.2) | 2.2 (3.9) | 3.2 (4.6) | 5.4 (14.6) | 3.4 (8.2) | |
| [min, max] | [0.15, 53.6] | [0.15, 34.0] | [0.10, 29.0] | [0.06, 194.6] | [0.1, 194.6] | |
| LBP | ||||||
| M(SD) | 5069 (2220) | 5562 (1947) | 4150 (1918) | 5225 (2368) | 5082 (2192) | |
| [min, max] | [221, 14,218] | [442, 10,719] | [429, 10,504] | [890, 17,070] | [221, 17,070] | |
| CES-D | ||||||
| M(SD) | 13.8 (10.5) | 10.2 (8.6) | 7.7 (7.1) | 9.4 (6.7) | 11.1 (9.1) | |
| [min, max] | [0, 49] | [0, 46] | [0, 41] | [0, 34] | [0, 49] | |
| CES-D clinical cutoff, %(n) | ||||||
| <16 | 62% (270) | 79% (211) | 87% (141) | 83% (208) | 74% (830) | |
| 16+ | 38% (165) | 21% (55) | 13% (21) | 17% (44) | 26% (285) |
IL-6 = interleukin-6, TNF-α = tumor necrosis factor-α, CRP = C-reactive protein, LBP = lipopolysaccharide-binding protein, CES-D = Center for Epidemiological Studies Depression Scale.