Table 1:
Baseline characteristic of all IPD cases, by era of IPD diagnosis.
| Characteristic | Pre-PCV13 (2002–2010, N=115) | Post-PCV13 (2011–2018, N=72) | Total (N=187) |
|---|---|---|---|
|
| |||
| Sex | |||
| Female | 56 (48.7%) | 34 (47.2%) | 90 (48.1%) |
| Male | 59 (51.3%) | 38 (52.8%) | 97 (51.9%) |
| Age at IPD diagnosis (years) | |||
| Mean (SD) | 56.3 (26.6) | 62.8 (27.1) | 58.8 (26.9) |
| Median (IQR) | 62.2 (46.9, 76.2) | 70.4 (49.5, 84.0) | 65.2 (46.9, 79.9) |
| Range | (0.6–97.7) | (1.0–99.6) | (0.6–99.6) |
| Race | |||
| White | 99 (86.1%) | 65 (90.3%) | 164 (87.7%) |
| Black or African American | 6 (5.2%) | 3 (4.2%) | 9 (4.8%) |
| Asian | 2 (1.7%) | 1 (1.4%) | 3 (1.6%) |
| American Indian/Alaskan Native | 1 (0.9%) | 0 (0.0%) | 1 (0.5%) |
| Other | 4 (3.5%) | 3 (4.2%) | 7 (3.7%) |
| Unknown/Not disclosed | 3 (2.6%) | 0 (0.0%) | 3 (1.6%) |
| Ethnicity | |||
| Hispanic or Latino | 5 (4.3%) | 3 (4.2%) | 8 (4.3%) |
| Not Hispanic or Latino | 86 (74.8%) | 67 (93.1%) | 153 (81.8%) |
| Unknown/Not disclosed | 24 (20.9%) | 2 (2.8%) | 26 (13.9%) |
| Comorbidities | |||
| Weighted CCI, median (IQR) | 3 (1, 9) | 6 (2, 10.5) | 4 (1, 9) |
| Myocardial infarction | 23 (20.0%) | 10 (13.9%) | 33 (17.6%) |
| Congestive heart failure | 39 (33.9%) | 31 (43.1%) | 70 (37.4%) |
| Peripheral vascular disease | 23 (20.0%) | 33 (45.8%) | 56 (29.9%) |
| Cerebrovascular disease | 30 (26.1%) | 18 (25.0%) | 48 (25.7%) |
| Dementia | 10 (8.7%) | 12 (16.7%) | 22 (11.8%) |
| Chronic pulmonary disease | 69 (60.0%) | 44 (61.1%) | 113 (60.4%) |
| Ulcer | 17 (14.8%) | 6 (8.3%) | 23 (12.3%) |
| Mild liver disease | 17 (14.8%) | 20 (27.8%) | 37 (19.8%) |
| Diabetes mellitus | 25 (21.7%) | 27 (37.5%) | 52 (27.8%) |
| Diabetes with organ damage | 12 (10.4%) | 15 (20.8%) | 27 (14.4%) |
| Hemiplegia | 8 (7.0%) | 6 (8.3%) | 14 (7.5%) |
| Moderate/severe renal disease | 32 (27.8%) | 20 (27.8%) | 52 (27.8%) |
| Moderate/severe liver disease | 2 (1.7%) | 6 (8.3%) | 8 (4.3%) |
| HIV or AIDS | 0 (0.0%) | 2 (2.8%) | 2 (1.1%) |
| Rheumatologic disease | 10 (8.7%) | 11 (15.3%) | 21 (11.2%) |
| Metastatic solid tumor | 16 (13.9%) | 11 (15.3%) | 27 (14.4%) |
| Other cancer | 43 (37.4%) | 31 (43.1%) | 74 (39.6%) |
| Body mass index (kg/m2) b | N=98 | N=63 | N=161 |
| < 18.5 | 6 (6.1%) | 4 (6.3%) | 10 (6.2%) |
| 18.5- <25 | 29 (29.6%) | 20 (31.7%) | 49 (30.4%) |
| 25 - <30 | 19 (19.4%) | 13 (20.6%) | 32 (19.9%) |
| 30+ | 33 (33.7%) | 24 (38.1%) | 57 (35.4%) |
| Not documented | 11 (11.2%) | 2 (3.2%) | 13 (8.1%) |
| Mean (SD) | 28.3 (8.5) | 28.6 (8.0) | 28.4 (8.3) |
a
Abbreviation: AIDS, acquired immunodeficiency disease syndrome; CCI, Charlson comorbidity index; HIV, human immunodeficiency virus; IQR, interquartile range; IPD, invasive pneumococcal disease; N, number; SD, standard deviation
b
Among patients diagnosed with IPD at age 18 years or greater