Table 1.

β-TrCP substrates that are modified by the proteasome-mediated limited processing.

Substrate (Also Known as)	Prior Phosphorylation by	Biological Functions by β-TrCP-Mediated Processing	β-TrCP Paralogue	Role in Cancer	Ref.
GLI3	CK1/GSK3	processed into GLI3-83 repressor (GLI3R)	β-TrCP1	suppressive	[78]
NFKB1 (NF-κB p105)	IKKβ	converted into subunit p50, leading to the formation of active NF-κB heterodimers	β-TrCP1/2	promoting	[68]
NFKB2 (NF-κB p100)	IKKα	converted into subunit p52 to form active NF-κB heterodimers	β-TrCP1	promoting	[75,79]
SP1	Cyclin A/CDK2	stabilizes and activates SP1 transcription factor	not specified	promoting	[77]