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. 2023 Apr 13;147(22):1640–1653. doi: 10.1161/CIRCULATIONAHA.122.060757

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© 2023 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Adjusted mean change in KCCQ-12 with FCM versus placebo, by baseline hemoglobin level. A, KCCQ-12 OSS; B, KCCQ-12 CSS. *P<0.05, **P<0.01 for FCM vs placebo in the low hemoglobin level ≥12 g/dL subgroup only. Error bars are standard error of the mean. Estimates are based on a mixed-effect model of repeated measures using an unstructured covariance matrix: change score = baseline score + treatment + visit + treatment × visit + subgroup + subgroup × visit + subgroup × treatment + subgroup × treatment × visit + baseline covariates. CSS indicates clinical summary score; FCM, ferric carboxymaltose; Hb, hemoglobin; KCCQ-12, 12-item Kansas City Cardiomyopathy Questionnaire; and OSS, overall summary score.