Figure 3.

Oncolytic virotherapy with G47Δ. (A) G47Δ, an oncolytic HSV-1, enters the tumour cell through receptor-mediated endocytosis. Once inside the cell, it undergoes viral replication, leading to the release of virus progeny. (B) Once G47Δ enters the tumour cell, cell lysis leads to proliferation of the viral progeny and the release of offspring viruses and cytokines such as IFNs. This activates APCs such as DCs, which further mature the cytotoxic T lymphocytes, such as CD8⁺ T cells, leading to immune stimulation. HSV-1 (Herpes simplex virus 1), interferons (IFNs), antigen-presenting cells (APCs), dendritic cells (DCs). Created with BioRender.com.