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. 2023 Aug 30;24(17):13494. doi: 10.3390/ijms241713494

Figure 5.

Figure 5

CORT alleviates liver injury by decreasing intestinal permeability. (A) Concentration of serum FITC-dextran 4 kDa to assess the change in intestinal permeability, n = 4 per group. Data are shown as the mean ± SD from each group. Statistical analysis was performed via one-way ANOVA: ** p < 0.01. (B) Concentration of serum LPS in the sham, BDL, and BDL+CORT mice groups, n = 4 per group. Data are shown as the mean ± SD from each group. Statistical analysis was performed via one-way ANOVA: * p < 0.05. (C) Relative mRNA levels of LPS-related genes in sham, BDL, and BDL+CORT mice livers. Actb was used as a reference gene, n = 4 per group. Data are shown as the mean ± SD from each group. Statistical analysis was performed via one-way ANOVA: ** p < 0.01. ns: no significant. (D) Sirius Red staining of sham, BDL, and BDL+CORT mouse livers and quantification of the Sirius Red-positive area, n = 4 per group. Data are shown as the mean ± SD from each group. Statistical analysis was performed via one-way ANOVA: *** p < 0.005. (E) Serum concentrations of ALT, AST, and ALP in sham, BDL, and BDL+CORT mice, n = 4 per group. Data are shown as the mean ± SD from each group. Statistical analysis was performed via one-way ANOVA: ** p < 0.01, *** p < 0.005 and **** p < 0.001. (F) Relative mRNA levels of inflammatory cytokines in sham, BDL, and BDL+CORT mice livers. Actb was used as a reference gene, n = 4 per group. Data are shown as the mean ± SD from each group. Statistical analysis was performed via one-way ANOVA: * p < 0.05, ** p < 0.01, and **** p < 0.001. ns: no significant.