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. 2023 Aug 29;24(17):13381. doi: 10.3390/ijms241713381

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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NLK blood glucose regulation mechanism. (Left) NLK regulates blood glucose by inhibiting the nuclear output of CRTC2. (Right) NLK regulates blood glucose by inhibiting the nuclear output of FoxO1. Abbreviations: NLK, Nemo-like kinase; CRTC2, cAMP response element-binding protein-regulated transcriptional coactivator; CREB, cAMP response element-binding protein; 2PCK1, phosphoenolpyruvate carboxykinase; and G6PC, glucose-6-phosphatase catalytic subunit. Tip arrows: activation; Flat arrows: inhibition.