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. 2023 Aug 23;24(17):13077. doi: 10.3390/ijms241713077

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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NSCLC histological phenotypes in case 3. Left panels: Diagnostic biopsy (baseline) from a metastasis to the thoracic lymph nodal station 4R with phenotype of lung adenocarcinoma (LAC); hematoxylin-eosin staining (H&E) shows malignant adeno-papillary structures, which are positive for the immunohistochemical LAC biomarker TTF1 (TTF1). Right panels: Rebiopsy from progressive metastasis in the left lung shows tumor transformation to squamous cell carcinoma (SCC); hematoxylin-eosin staining (H&E) shows a solid, slightly keratinizing tumor tissue, which is positive for the immunohistochemical SCC biomarker p40 (p40). (All magnifications, ×200).