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. 2023 Aug 24;24(17):13171. doi: 10.3390/ijms241713171

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of psoralen on UUO-induced renal inflammasome activation. Expression levels of NLRP-3 and cleaved caspase-1 (cCasp-1) were analyzed by Western blot. (A) Quantitative analyses of NLRP-3 and cCasp-1 were performed with results normalized to β-actin (B). mRNA expression levels of IL-1β and IL-18 were measured by quantitative real-time PCR (C). Double immunofluorescence staining for macrophage (green) and NLRP3 (red). White square boxes are representative double-positive signals for macrophage and NLRP3. Scale bar, 100 μm (D). In this figure, each dot in the sham group represents the average value of three mice in that group as “1”. Data are presented as mean ± SEM. * p < 0.05.

Effects of psoralen on UUO-induced renal inflammasome activation. Expression levels of NLRP-3 and cleaved caspase-1 (cCasp-1) were analyzed by Western blot. (A) Quantitative analyses of NLRP-3 and cCasp-1 were performed with results normalized to β-actin (B). mRNA expression levels of IL-1β and IL-18 were measured by quantitative real-time PCR (C). Double immunofluorescence staining for macrophage (green) and NLRP3 (red). White square boxes are representative double-positive signals for macrophage and NLRP3. Scale bar, 100 μm (D). In this figure, each dot in the sham group represents the average value of three mice in that group as “1”. Data are presented as mean ± SEM. * p < 0.05.