Skip to main content
. 2023 Sep 3;24(17):13618. doi: 10.3390/ijms241713618
NSCLC non-small cell lung cancer
EGFR epidermal growth factor receptor
TKI tyrosine kinase inhibitor
PFS progression-free survival
FGFR fibroblast growth factor receptor
IGF1R insulin-like growth factor 1 receptor
AXL anexelekto
ALK anaplastic lymphoma kina
EML4 echinoderm microtubule-associated protein-like 4
MET mesenchymal-epithelial transition
ORR objective response rate
KIT mast/stem cell growth factor receptor
RTK receptor tyrosine kinase
HGF hepatocyte growth factor
FDA Food and Drug Administration
VEGF vascular endothelial growth factor
IFL irinotecan, bolus fluorouracil, and leucovorin
FOLFOX4 oxaliplatin, fluorouracil, and leucovorin
FOLFIRI 5-fluorouracil, leucovorin, and irinotecan
VEGFR VEGF receptor
ADCC antibody-dependent cellular cytotoxicity
TGF-β transforming growth factor-beta
TβRI TGFβ receptor I
HER2 human epidermal growth factor receptor 2
TMB tumor mutational burden
MSI-H microsatellite instability-high
dMMR deficient mismatch repair
AR androgen receptor
DHT dihydrotestosterone
LHRH luteinizing hormone-releasing hormone
CAB complete androgen blockade
ADT androgen deprivation therapy
DHEA dehydroepiandrosterone
mCRPC metastatic castration-resistant prostate cancer
nmCRPC non-metastatic castration-resistant prostate cancer
mHSPC metastatic hormone-sensitive prostate cancer
mCSPC metastatic castration-sensitive prostate cancer
HRR homologous recombination repair
DDR DNA damage response
NHEJ non-homologous end joining
MMR mismatch repair
PSA prostate specific antigen
NDA new drug application
PSMA prostate-specific membrane antigen
MAPK mitogen-activated protein kinase
CDK12 cyclin-dependent kinase 12
ICI immune checkpoint inhibitor
HRD homologous recombination deficiency