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. 2023 Aug 25;12(17):5518. doi: 10.3390/jcm12175518

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Trephine biopsy—bone marrow occupied by the sheets of abnormal histiocytes. H&E. Obj. magn. ×20. (b) Trephine biopsy—a sheet of histiocytes (Gaucher’s cells) with an abundant eosinophilic (arrow) or clear cytoplasm with irregular vacuoles (arrowhead). H&E. Obj. magn. ×40. (c) Trephine biopsy—abnormal histiocytes with very weak cytoplasmic PAS positivity. Periodic acid-Schiff staining. Obj. magn. ×40. (d) Trephine biopsy—histiocytes stained for immunoglobulin kappa light chains. Kappa light chain immunostaining. Obj. magn. ×40.

(a) Trephine biopsy—bone marrow occupied by the sheets of abnormal histiocytes. H&E. Obj. magn. ×20. (b) Trephine biopsy—a sheet of histiocytes (Gaucher’s cells) with an abundant eosinophilic (arrow) or clear cytoplasm with irregular vacuoles (arrowhead). H&E. Obj. magn. ×40. (c) Trephine biopsy—abnormal histiocytes with very weak cytoplasmic PAS positivity. Periodic acid-Schiff staining. Obj. magn. ×40. (d) Trephine biopsy—histiocytes stained for immunoglobulin kappa light chains. Kappa light chain immunostaining. Obj. magn. ×40.