Table 3.

Literature comparison of sleeve gastrectomy and Roux-en-Y gastric bypass in terms of remission of gastroesophageal reflux symptoms and the use of acid suppression medications. ACM = acid suppression medications, EE = erosive esophagitis, GERD = gastroesophageal reflux disease, OR = odds ratio, PPI = proton pump inhibitors, (L)RYGB = (laparoscopic) Roux-en-Y gastric bypass, (L)SG = (laparoscopic) sleeve gastrectomy.

Comparison of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass in Terms of Gastroesophageal Reflux Symptom Remission and the Use of Acid Suppression Medications
Author	Year	Journal	Article Type	Number of Cases/Studies	GERD Symptom Remission—RYGB	Pre- and Post-Operative Usage of Acid Suppression Medications (ACM)	GERD Symptom Remission—SG	p-Value	Additional Comments
Peterli et al. [50]	2018	JAMA	Randomized controlled trial	217	60.4%	N/R	25%	0.002	De novo reflux in 31.6% after SG vs. 10.7% after RYGB (p = 0.01)
Alghamdi et al. [53]	2022	Frontiers in Surgery	Systematic review, meta-analysis	16	Odds ratio of GERD remission = 3.16 for LRYGB compared to LSG, p = 0.003, heterogeneity N/A Usage of ACM was not reported				There was no significant statistical difference between LRYGB and LSG with regard to new-onset GERD; heterogeneity was noted
Gu et al. [11]	2019	Obesity Surgery	Systematic review, meta-analysis	23	OR for GERD after LSG compared to LRYGB = 5.10, p < 0.001 LRYGB had a better effect on GERD compared to LSG, OR = 0.19, p < 0.001
DuPree et al. [16]	2014	JAMA Surgery	Retrospective review	4832	62.8%	N/A	15.9%	p < 0.001	New-onset GERD was noted in 8.6% in the LSG group
Sheppard et al. [12]	2015	Obesity Surgery	Retrospective review	387	Pre-operative PPI use in LSG: 28% → 2% were able to discontinue PPI after SG Pre-operative PPI use in LRGYB: 32% → 33% were able to discontinue PPI after RYGB
Matar et al. [15]	2020	Obesity Surgery	Retrospective review	517	EE prevalence higher after SG than RYGB (37.9% vs. 17.6%, p = 0.0001)