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. 2023 Aug 27;12(17):5588. doi: 10.3390/jcm12175588

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Illustrative comparison of cardiovascular imaging and histology data of two exemplar patients: electrocardiography (Column 1), global longitudinal strain (GLS; Column 2), matching native T1 (Column 3), and collagen volume fraction (CVF) in myocardial biopsies stained with Masson’s trichrome (Column 4). Patient without ECG changes (A) has preserved GLS, low native T1, and low histological fibrosis (CVF of 1.3%), whereas patient with ECG strain (B) has significantly reduced GLS, high native T1, and extensive histological fibrosis (CVF 23.5%).