Table 3.
Sub-analysis of demographic and biochemical characteristics of subjects with T2DM according to the presence of significant CAD.
| No CAD | CAD | p | |
|---|---|---|---|
| Characteristics | |||
| N | 30 | 103 | |
| Age (years) | 63 (54.8–73) | 68 (61–75) | 0.16 |
| Sex (% male) | 20 (66.7) | 65 (63.1) | 0.83 |
| BMI (kg/m2) | 26.8 ± 2.2 | 27.3 ± 2.9 | 0.13 |
| SBP (mm Hg) | 129 ± 10.1 | 132 ± 11.1 | 0.04 |
| DBP (mm Hg) | 75.3 ± 7.7 | 75.9 ± 9.1 | 0.47 |
| Comorbidities | |||
| Obesity | 4 (13.3) | 10 (9.7) | 0.52 |
| Hypertension (%) | 6 (20) | 31 (30.1) | 0.36 |
| Former smoker (%) | 7 (23.3) | 21 (20.4) | 0.12 |
| Current smokers (%) | 7 (23.3) | 19 (18.4) | 0.21 |
| Dyslipidemia (%) | 10 (33) | 44 (42.7) | 0.41 |
| Laboratory data | |||
| T-cholesterol (mg/dL) | 160.5 (134.5–188.5) | 168 (142–193) | 0.47 |
| HDL-C (mg/dL) | 34 (27.3–42.8) | 38 (31–44) | 0.26 |
| LDL-C (mg/dL) | 90.5 (70.3–118.5) | 95 (75–110) | 0.84 |
| TG (mg/dL) | 142.5 (114.5–200) | 142 (114–197) | 0.97 |
| TyG index | 5.08 (4.9–5.26) | 5.03 (4.9–5.25) | 0.76 |
| FG (mg/dL) | 133.8 (67.2–222) | 162 (142–196) | 0.28 |
| Hb1ac (%) | 7.42 ± 0.2 | 7.58 ± 0.21 | 0.11 |
| eGFR (mL/min/1.73 m2) | 99.8 ± 10.3 | 96.9 ± 9.3 | 0.16 |
| Creatinine (mg/dL) | 0.84 (0.71–0.99) | 0.82 (0.7–1.1) | 0.64 |
| ACR (mg/g) | 5.76 (3.22–13.84) | 9 (4.3–19) | 0.08 |
| Uric acid (mg/dL) | 5.36 (4.35–6.89) | 5.36 (4.45–6.11) | 0.99 |
| Calcium (mg/dL) | 9.3 ± 0.34 | 9.36 ± 0.28 | 0.85 |
| Phosphate (mg/dL) | 3.55 ± 0.71 | 3.55 ± 0.42 | 0.98 |
| NLR (/mL) | 2.58 (1.62–3.89) | 2.2 (1.8–3.52) | 0.69 |
| MLR (/mL) | 0.33 (0.23–0.46) | 0.32 (0.24–0.43) | 0.86 |
| hs-CRP (mg/L) | 2.75 (1.25–5.9) | 3.9 (2.1–6.8) | 0.03 |
| TNFα (pg/mL) | 1.87 (1.34–2.72) | 2.22 (1.57–3.1) | 0.04 |
| IL6 (pg/mL) | 5.03 (2.48–8.97) | 7.5 (3.51–12–25) | 0.03 |
| Klotho (pg/mL) | 314.5 (6.15–562.81) | 458.97 (275.2–667.2) | 0.02 |
| iFGF23 (pg/mL) | 571.2 (444.5–675.4) | 570.21 (421.3–707.3) | 0.91 |
| Medication | |||
| Statin (%) | 21 (70) | 63 (61.2) | 0.38 |
| ACEI/ARB (%) | 11 (36.7) | 50 (48.5) | 0.25 |
CAD, coronary artery disease; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C high density lipoprotein cholesterol; LDL-C low-density lipoprotein cholesterol; TG, triglycerides; TyG, triglyceride glucose index; FG, fasting glucose; Hb1ac, glycated hemoglobin; eGFR, estimated glomerular filtrate rate; ACR, urine albumin-to-creatinine ratio; hs-CRP high sensitivity C-reactive protein, TNFα, tumor necrosis factor alpha; IL, interleukin; NLR, neutrophil lymphocyte ratio; MLR, monocyte lymphocyte ratio; iFGF23, intact fibroblast growth factor 23; ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin II receptor antagonist.