Table 1.

Genotype distribution and allele frequency of ERAP1 and ERAP2 SNPs in B*27:05-positive pEBNA3A responders versus non-responders.

		pEBNA3A Responders (N = 73)		pEBNA3A Non-Responders (N = 29)
	Genotype	N	(%)	N	(%)
ERAP1 rs27044 C/G Glu730Gln	CC	20	27.4	12	41.4
	GC	42	57.5	15	51.7
	GG	11	15.1	2	6.9
	Allele
	C	82	56.2	39	67.2
	G	64	43.8	19	32.8
	Genotype	N	(%)	N	(%)
ERAP1 rs30187 C/T Arg528Lys	CC	7	9.6	11	37.9	*** p value 0.0007 (CC vs. TT + CT)
	CT	48	65.7	12	41.4
	TT	18	24.7	6	20.7
	Allele
	C	62	42.5	34	58.6	* p value 0.037
	T	84	57.5	24	41.4
	Genotype	N	(%)	N	(%)
ERAP2 rs75862629intergenic region A/G	AA	58	79.5	25	86.2
	AG	13	17.8	4	13.8
	GG	2	2.7	0	0.0
	Allele
	A	129	88.4	54	93.1
	G	17	11.6	4	6.9
	Genotype	N	(%)	N	(%)
ERAP2 rs2248374 G-> absence A -> presence	GG	17	23.3	7	24.1
	AG	43	58.9	20	69.0
	AA	13	17.8	2	6.9
	Allele
	G	77	52.7	34	58.6
	A	69	47.3	24	41.4

The allelic and genotype frequencies for each SNP in B*27:05-positive pEBNA3A responders versus pEBNA3A non-responders are reported. The AS-risk variants are indicated in red. The C variant for rs30187 is more frequent in the pEBNA3A non-responders, both as allelic (* p value = 0.037) and genotype frequency (CC vs. CT + TT) (*** p value = 0.0007). Chi-square test; * p value < 0.05; *** p value < 0.001.