Figure 11.

The cytokine network in transwell co-cultures of primary AML cells and normal MSCs. Primary AML cells were derived from 18 unselected patients, and the levels of 17 mediators were determined in the supernatants harvested after 48 h of co-culture. This clustering is based on the relative mediator levels, i.e., the levels in supernatants derived from inhibitor-containing co-cultures relative to the levels in supernatants derived from drug-free control cultures. Bafilomycin (left) and concanamycin (right) were tested at a final concentration of 10 nM.