Skip to main content
. 2023 Aug 30;24(17):13490. doi: 10.3390/ijms241713490

Figure 4.

Figure 4

GABA uptake blockers prolong ePSC decay only in adult NG2 glia. (A,C) Original recordings of ePSCs in NG2 glia at p10 and p60 before (black trace) and after application (red) of NNC-711 (A, 10 µM) and SNAP-5114 (C, 100 µM). Bath solution contained 10 µM NBQX, 50 µM D-APV and 5 µM CGP55845. (B,D) Plots comparing changes in decay time constant (mono-exponential fit) after application of NNC-711 (B; p10 control: 30.52 ± 8.72 ms; NNC-711: 32.22 ± 10.66 ms, n = 7, N = 5; p = 0.73; p60 control: 78.42 ± 31.14 ms; NNC-711: 190.96 ± 60.32 ms, n = 7, N = 4; p < 0.001) and SNAP-5114 (D; p10: control: 33.95 ± 21.63 ms; SNAP-5114: 31.35 ± 14.41 ms, n = 7; N = 4; p = 0.53; p60 control: 56.83 ± 19.45 ms; SNAP-5114: 83.18 ± 30 ms, N = 3, n = 7; p < 0.01). Thus, only at the adult stage, inhibition of GABA uptake slowed ePSC decay. Paired t-test; ** p < 0.01, *** p < 0.001.