Table 3.

Clusters of significant differences in fractional anisotropy (FA) between cocaine use disorder (CocUD) and control subjects

Cluster no.	ROI(s)	Cluster size (voxels)	X	Y	Z	Cohen's d	Sex-matched Cohen's d
1	RILF	10	43.4	-19.8	-4.1	0.63	0.04
2	RILF	15	43.2	-24.7	2.93	0.62	0.01
3	R SLF	58	49.5	-25.3	-14.4	0.56	0.35
4	GCC, BCC, SCC, L ACR, L/R SCR, L/R PCR, R PTR, L CG	2,499	6.61	-24	27.3	0.38	0.18

Notes: The clusters reported here were identified using the autoaq command and met the inclusion threshold of p < .025 (two tailed, p < .05). The clusters reported here were regions in which FA was significantly lower in CocUD subjects than in healthy controls. X, Y, and Z coordinates are mm in MNI space and represent the center of gravity for each cluster. Sex-matched d refers to the Cohen's d for the same clusters in the sex-matched sample. No. = number; ROI = region of interest; ACR = anterior corona radiate; BCC = body of the corpus callosum; CG = cingulum; GCC = genu of the corpus callosum; ILF = inferior longitudinal fasciculus; PCR = posterior corona radiate; PTR = posterior thalamic radiation; SCC = splenium of the corpus callosum; SCR = superior corona radiate; SLF = superior longitudinal fasciculus.