Scheme 29.

Synthesis of 110. Reagents and conditions: (i) 1. epichlorohydrine, RT, 3 h; 2. H₂SO₄, 140 °C, 1 h; 3. H₂O, CHONH₂, 145 °C, 20 h; (ii) H₂, Pd/C, MeOH, RT, 1 h; (iii) 1. 2-(6-bromohexyl)isoindoline-1,3-dione, N,N-diisopropylethylamine (DIPEA), DMF, 100 °C, 20 h; 2. TosCl, NEt₃, CH₂Cl₂, RT, 20 h; (iv) H₄N₂·H₂O, EtOH, 80 °C, 1.5 h; (v) 1. p-nitrophenyl chloroformate, NEt₃, CH₂Cl₂, 3 h, RT; 2. 13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino [1,2-b]quinazolin-10-ol, NaH, CH₂Cl₂, 2 h, RT; (vi) TMS Cl, para-formaldehyde, CH₂Cl₂, RT, 18 h; (vii) MeOH, RT, 1 h; (viii) 1. [ ¹⁸F]KF, K₂₂₂, MeCN, 110 °C, 10 min; 2. 6 M HClaq, 90 °C, 5 min.