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. 2023 Aug 23;28(17):6201. doi: 10.3390/molecules28176201

Figure 8.

Figure 8

An example of the outstanding potential of offline AF4-nUHPLC to the lipidomic analysis of lipoproteins, which allowed the recognition of 363 lipidic species. PCA (A) and Vulcano (A′) analysis allowed a fast preliminary identification of lipids to differentiate the samples. (B,B′) represent absolute and percent composition of the lipids of eight different classes in the MCI, AD, and control samples. More than twofold differences in abundance were observed for certain lipidic classes when comparing the LDL/VLDL of the AD and MCI to the control ones. (C) Represents the correlation between the abundance of three prominent lipid species in HDLs and LDLs/VLDLs with certain diseases. (C′) Represents the ROC curves of the four candidate markers: two in MCI in combination with MMSE scores (solid line) superimposed with those of MMSE scores alone (dotted line) [148].