Table 4.
The effect of intermittent vitamin D supplementation method on 25(OH)D concentration (nmol/L), compared to daily supplementation using network meta-analysis.
| Detecting | Total dose | Average dose | Weekly | Monthly | ||
|---|---|---|---|---|---|---|
| Time | IU | IU/day | N | Pooled MD (95%CI) | N | Pooled MD (95%CI) |
| 2 Months | 36,000 | 600 | – | – | 2 | −19 (−45,5) |
| 100,000 | 1,666 | 2 | −9 (−38,21) | 5 | −5 (−26,17) | |
| 200,000 | 3,333 | 5 | 15 (−26,55) | – | – | |
| 3 Months | 90,000 | 1,000 | 3 | −10 (−34,13) | – | – |
| 180,000 | 2,000 | – | – | 4 | −6 (−29,19) | |
| 300,000 | 3,333 | 9 | 0 (−22,22) | – | – | |
| 600,000 | 6,666 | 22 | −11 (−59,37) | – | – | |
| 6 Months | 300,000 | 1,666 | – | – | 4 | −8 (−25, 8) |
| 600,000 | 3,333 | 13 | −11 (−37,16) | – | – | |
| 12 Months | 720,000 | 2,000 | – | – | 4 | −18 (−32, −4) |
MD indicates mean difference. Number in bold indicates its p value less than 0.05.