Table 1.

Names, structures, and inhibition constants of co-crystalized 5-HT_2AR and 5-HT_2BR ligands.

PDB ID P (Mechanism) a	Compound’s Structure	pKi	Ref.	PDB ID P (Mechanism) a	Compound’s Structure	pKi	Ref.
5-HT2AR ligand				7WC7 AG		8.55	[26]
6A93 FA a		8.16	[16]	7WC8 AG		9.27	[26]
6A94 FA		7.40	[16]	7WC9 AG		NA	[26]
6WGT 7WC6 AG		8.63	[16] [26]	5-HT2BR ligand
6WH4 IA		9.70	[25]	4NC3 4IB4 5TUD AG		8.88	[29] [29] [31]
6WHA PA		9.08	[25]	5TVN AG		NA	[31]
7RAN AG		NA a	[27]	6DRX AG		8.88	[33]
7VOD FA		7.73	[28]	6DRY 7SRQ 7SRS 7SRR AG		9.33	[33] [32] [32] [32]
7VOE FA		8.47	[28]	6DRZ AG		10	[33]
7WC4 AG		7.49	[26]	6DS0 FA		NA	[33]
7WC5 AG PA		NA	[26]

^a Pharmacology: AG—agonist, IA—inverse agonist, PA—partial agonist, FA—full antagonist