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. 2023 Aug 24;28(17):6236. doi: 10.3390/molecules28176236

Table 3.

Commercial names, structures, and inhibition constants of human 5-HT2AR ligands compiling the TS.

Name
(Number)
P (Mechanism) a 		Compound’s
Structure		 pKi Ref. Name
(Number)
P (Mechanism) a 		Compound’s
Structure		 pKi Ref.
Aripiprazole
(25) FA a 		graphic file with name molecules-28-06236-i044.jpg 8.57 [46] Norfenfluramine
(36) AG		 graphic file with name molecules-28-06236-i045.jpg 6.82 [47]
BW-723C86
(26) AG		 graphic file with name molecules-28-06236-i046.jpg 7.2 [48] Olanzapine
(37) IA		 graphic file with name molecules-28-06236-i047.jpg 8.88 [49]
Clozapine
(27) FA		 graphic file with name molecules-28-06236-i048.jpg 8.39 [50] Quentiapine
(38) FA		 graphic file with name molecules-28-06236-i049.jpg 6.81 [50]
CP-809,101
(28) AG		 graphic file with name molecules-28-06236-i050.jpg 8.22 [51] R060-0175
(39) IA		 graphic file with name molecules-28-06236-i051.jpg 7.44 [48]
Ketanserin
(29) FA		 graphic file with name molecules-28-06236-i052.jpg 9.67 [52] Risperidone
(40) IA		 graphic file with name molecules-28-06236-i053.jpg 9.69 [50]
Lorcaserin
(30) AG		 graphic file with name molecules-28-06236-i054.jpg 6.95 [53] RS-127,455
(41) FA		 graphic file with name molecules-28-06236-i055.jpg 6.03 [48]
MDL-100,907
(31) FA		 graphic file with name molecules-28-06236-i056.jpg 8.77 [54] Saprogrelate
(42) FA		 graphic file with name molecules-28-06236-i057.jpg 8.52 [55]
Mesulergine
(32) FA		 graphic file with name molecules-28-06236-i058.jpg 7.34 [56] SB-204,741
(43) FA		 graphic file with name molecules-28-06236-i059.jpg 5.00 [57]
Mianserin
(33) FA		 graphic file with name molecules-28-06236-i060.jpg 8.15 [58] SB-206,553
(44) FA		 graphic file with name molecules-28-06236-i061.jpg 5.64 [59]
Mirtazapine
(34) IA		 graphic file with name molecules-28-06236-i062.jpg 7.78 [60] SB-242,084
(45) FA		 graphic file with name molecules-28-06236-i063.jpg 6.07 [61]
Naftidrofuryl
(35) IA		 graphic file with name molecules-28-06236-i064.jpg 6.20 [55] WAY-161,503
(46) AG		 graphic file with name molecules-28-06236-i065.jpg 7.40 [62]

a Pharmacology: AG—agonist, IA—inverse agonist, PA—partial agonist, FA—full antagonist.