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. Author manuscript; available in PMC: 2024 Apr 6.
Published in final edited form as: Adv Mater Technol. 2023 Feb 3;8(7):2201778. doi: 10.1002/admt.202201778

Figure 9.

Figure 9.

a) Schematic of HGPS pathogenesis. Mutations of the LMNA gene, such as C1824T, lead to aberrant mRNA splicing and permanent farnesylation of lamin A, i.e., progerin, that accumulates at the nuclear periphery. Reproduced with permission.[299] Copyright 2014, Elsevier. b) Schematic of blood vessel chips to investigate HGPS hiPSC-SMCs under mechanical stimuli. c) Both healthy and HGPS hiPSC-SMCs exhibit improved alignment under 16% strain. #, P < 0.0001. Red arrow indicates stretching direction. Scale bar, 50 μm. d) 16% mechanical strain leads to DNA double-strand breaks (H2A.X immunostaining) and a slight increase of senescence (β-galactosidase-induced fluorescence) of HGPS hiPSC-SMC. b-d) Reproduced with permission.[246] Copyright 2017, John Wiley and Sons.