Table 4.

The genetic inheritance of the RB1 mutation in the cohort.

Genetic inheritance	RB1 mutations		Total n(%)	Significance
	No n(%)	Yes n(%)
De novo/heritable**
	0 (0%)	44 (100%)	44 (32.4%)	p: 0.000*
Hereditary/familial***
	0 (0%)	13 (100%)	13 (9.5%)
Non-hereditary for RB1 gene mutations****
	79 (100%)	0 (0%)	79 (58.1%)
Total	79 (58.1%)	57 (41.9%)	136 (100%)

RB1 = retinoblastoma gene.

^*P < .05 is significant.

^**De novo: no family history of retinoblastoma, but the patient was a carrier of RB1 gene mutation and was the first index case.

^***A family history of retinoblastoma and the patient was a carrier of the RB1 gene mutation.

^****No family history of retinoblastoma, and the patient was not carry RB1 gene mutation.