Figure 9.

HFD exacerbated Aβ plaque load in the cortices of 10-month-old APP/PS1 mice. Representative photomicrographs of the brains of APP/PS1 mice fed either with STD at 6 months or (B) 10 months (C) or HFD at 3 months (D), 6 months (E) and 10 months (F) of age and the WT control at 10 months of age (G) immunohistochemically stained (A–F) for human Aβ and their quantification (G,H). Aβ plaque load is expressed as a percentage of the stained area. The data are presented as the means ± SD. Statistical analysis was made via one-way ANOVA with Bonferroni post hoc test (n = 5–8 mice per group). The significance of changes induced by diet: *: p < 0.05, by age: ^XXX: p < 0.001, by genotype: #: p < 0.05, ##: p < 0.01, ###: p < 0.001.