TABLE 3.
Relationship between the patterns of reactivity with VP4 NtMAbs and the genomic P types of HRV-positive specimens
| VP4 geno- mic typea | No. of specimens that reacted with the indicated MAbsb
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| F45, 1A10 (Ac) | F45 (B) | 1A10 (C) | F45, 1A10, RV5 (D) | F45, RV5 (E) | 1A10, RV5 (F) | RV5 (G) | HS6 (H) | Total | |
| P[8] | 27 | 7 | 2 | 7 | 2 | —d | — | — | 45 |
| P[4] | — | — | 1 | — | — | 2 | 3 | — | 6 |
| P[6] | — | — | — | — | — | — | — | 1 | 1 |
| Total | 27 | 7 | 3 | 7 | 2 | 2 | 3 | 1 | 52 |
a
All genotype P[8] strains had a G1 or G3 VP7 serotype specificity; all P[4] viruses were serotype G2; the single P[6] strain belonged to serotype G3. These findings are in agreement with the known association between G serotypes and genomic P types.
b
The P serotypes of the viruses used to generate the VP4 NtMAbs are P1A for MAbs 1A10 and F45, P1B for MAb RV5, and P2A for MAb HS6.
c
For simplicity during their reference in the text, the VP4 MAb patterns found were designated A to H.
d
—, no specimen having the indicated pattern of reactivity with the VP4 MAbs and genomic P type was identified.