Table 2.
PLGA/PLA/Chitosan nanocomposites containing natural products and anticancer agents for biological application.
| SN. | Polymers and Auxiliary Material Used | Antibiotics Used | Description of Formulation | Biological Activity | References | Year | ||
|---|---|---|---|---|---|---|---|---|
| 1 | PLGA | - | - | Plant extracts (as green surfactants), curcumin | Using green synthesis and nanoprecipitation, plant extract curcumin-loaded PLGA NPs are synthesized. | Improved solubility and photo stability | [151] | 2020 |
| 2 | PLGA | HPMC | - | Sweet potato leaves | Purple sweet potato leaf extracts loaded in PLGA submicroparticles to enhance the stability of flavonoids. | Antibacterial activity | ||
| 3 | PLGA | - | - | Thyme oil | PLGA was coated with thyme oil by coacervation process. | Antimicrobial | [153] | 2016 |
| 4 | PLGA | Silk fibroin | - | Aloe anthraquinone | PLGA, silk fibroin, is an antibacterial agent from natural source, aloe anthraquinone (AA), blended by electrospinning for wound healing. | Wound healing | [154] | 2022 |
| 5 | PLGA | - | - | Alstonia scholaris leaf extract | Using solvent displacement method, Alstonia scholaris leaf extract loaded, PLGA NPs formulated. | Antimicrobial activity | [152] | |
| 6 | Cur-PLGA Complexes | Lactic acid (LA) | Glycolic acid (SSC and AAT conformers) | Curcumin | - | Antimicrobial activity | [155] | 2021 |
| 7 | PLGA | Dextran | - | Curcumin | - | Antibacterial activity | [156] | 2021 |
| 8 | PLGA | - | - | Curcumin (CUR) | To deliver the curcumin and increase its solubility and antibacterial properties, PLGA NPs were used. | Antibacterial activity | [157] | 2020 |
| 9 | PLGA | - | - | Curcumin | Encapsulation of curcumin in PLGA NPs. | Antioxidant | [158] | 2015 |
| 10 | PLGA | - | - | Epigallocatechin-3-O-gallate (EGCG) | By using electrospinning nanofibers method, EGCG, encapsulated PLGA sheets were prepared. | Prevention of post-surgical adhesion formation. | [159] | 2015 |
| 11 | PLGA | - | - | Ginseng/polyaniline | Microcapsules were equipped with antibacterial properties by incorporating Polyaniline (PANI) in ginseng-loaded PLGA microcapsules. | Antibacterial activity | [160] | 2019 |
| 12 | PLGA | Dextran | - | Cisplatin (CDDP) | PLGA dextran (PLD) non-delivery system was developed to improve the anticancer property of cisplatin. | Targeting of Cisplatin in Osteosarcoma | [161] | 2015 |
| 13 | PLGA-TH-NPs | - | - | Thymus vulgaris (thymol), amikacin antibiotics | Thymol-encapsulated PLGA NPs were studied for their synergistic activity in combination with antibiotics amikacin. | Antibacterial activity | [162] | 2023 |
| 14 | PLGA | - | - | - | Orthodontic adhesive (OQ) was incorporated into curcumin-loaded PLGA NPs. | Antimicrobial | [163] | 2020 |
| 15 | Poly(sarcosine) (PSar) | PEG | PLGA | Docetaxel | Docetaxel encapsulated poly(sarcosine) (PSar) and Polyethylene glycol (PEG) coated PLGA NPs. | Anticancer | [164] | 2021 |
| 16 | PLGA | - | - | Anticancer drug—doxorubicin (DOX) hydrochloride. | CNTs (carbon nanotubes) were used as nanocarriers and loaded with Doxorubicin (DOX) hydrochloride; then, these CNTs were encapsulated into PLGA nanofibers by electrospinning technique. | Antitumor Activity | [165] | 2015 |
| 17 | PLGA | Porphyrin photosensitizer sinoporphyrin sodium (DVDMS) | carboxymethyl chitosan sodium alginate | Basic fibroblast growth factor (bFGF) | Porphyrin photosensitizer sino porphyrin sodium (DVDMS) and PLGA encapsulated with bFGF nanosphere—embedded in carboxymethyl chitosan–sodium alginate to form hybrid hydrogel. | Wound healing. | [166] | 2020 |