Table 1.
Critical results of network meta-analysis for the global condition and mental health condition in patients with IBS.
| Outcome | Efficacy Level A 1 | Efficacy Level B | Efficacy Level C | ||||
|---|---|---|---|---|---|---|---|
| Probiotic | NMA 2 | GRADE | Probiotic | NMA | GRADE | Probiotic | |
| IBS-SSS | L. acidophilus DDS-1 | −77.70 (−101.72, −53.68) |
M | EF + LA + X | −35.00 (−60.44, −9.56) |
M | L. acidophilus ATCC 700396, L. plantarum 299v, L. plantarum CCFM8610, L. casei LCR35, L. paracasei HA-196, B. longum R0175, BAL + ST + LB, LR + PF + X |
| BL + LR | −80.99 (−130.73, −31.26) |
M | B. bifidum MIMBb75 | −29.83 (−48.24, −11.42) |
H | ||
| LC + LP + BAL | −76.42 (−114.90, −37.95) |
M | C. butyricum CGMCC0313.1 | −21.38 (−40.47, −2.29) |
H | ||
| LP + LC + BL + ST + LA + X | −63.96 (−78.66, −49.26) |
M | BAL + LA + BB + X | −18.86 (−25.88, −11.85) |
M | ||
|
B. lactis UABla-12 |
−48.80 (−73.00, −24.60) |
M | |||||
| IBS-QOL | LP + LC + BL + ST + LA + X | 24.80 (20.65, 28.95) |
M | C. butyricum CGMCC0313.1 | 4.07 (0.50, 7.65) |
H | LP + LC + BL + ST + LA + X, S. boulardii CNCM I-475, LC + LP + BAL, LA + LR + ST + BL + BBR + X, EF + LA + X, BAL + ST + LB, LPA + LA + BAL, L. acidophilus ATCC 700396 |
| HADS-total score | B. longum R0175 | −0.34 (−0.48, −0.20) |
H | None | L. paracasei HA-196, L. acidophilus ATCC 700396 | ||
| HADS-anxiety | None | None | B. longum NCC3001, L. acidophilus ATCC 700396, LPA + LA + BAL | ||||
| HADS-depression | B. longum NCC3001 | −3.00 (−4.92, −1.08) |
H | None | L. paracasei CNCM I-1572, L. acidophilus ATCC 700396, LPA + LA + BAL | ||
1 Efficacy level A (among the most effective): probiotics that are significantly superior to placebo and at least 1 probiotic in level B. Efficacy level B: probiotics that are more effective than placebo, but not superior to any other of the probiotic(s) superior to placebo. Efficacy level C (among the least effective): probiotics with no significant difference compared to placebo. 2 The network meta-analysis results were the efficacy of probiotics compared to placebo. Mean difference with 95% confidence intervals in parentheses. Abbreviations: IBS-SSS, IBS Symptom Severity Scale; IBS-QOL, IBS-Quality of Life Measure; HADS, the Hospital Anxiety and Depression Scale; GRADE, The Grading of Recommendations, Assessment, Development and Evaluation system; H, high; M, moderate; L, low.