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. 2023 Sep 6;43(36):6249–6267. doi: 10.1523/JNEUROSCI.0247-23.2023

Figure 11.

Figure 11.

Decreased AHP amplitude in DAT-Cul3f/+ VTA DA neuron. A, Schematic diagram represents single AP recording. B, Enlarged trace for a single AP from VTA DA neurons of indicated genotypes. C, Comparable threshold for AP firing. n = 10 neurons, 4 mice for DAT-Cre:Td group; n = 9 neurons, 4 mice for DAT-Cul3f/+:Td group; p = 0.9300, t(13.55) = 0.0895; unpaired t test. D, Similar spike amplitude of APs. n = 10 neurons, 4 mice for DAT-Cre:Td group; n = 9 neurons, 4 mice for DAT-Cul3f/+:Td group; p = 0.9472, t(13.09) = 0.0676; unpaired t test. E, Similar half-width of APs. n = 10 neurons, 4 mice for DAT-Cre:Td group; n = 9 neurons, 4 mice for DAT-Cul3f/+:Td group; p = 0.8382, t(13.4) = 0.2082; unpaired t test. F, Decreased AHP. n = 10 neurons, 4 mice for DAT-Cre:Td group; n = 9 neurons, 4 mice for DAT-Cul3f/+:Td group; p = 0.0021, t(16.09) = 3.657; unpaired t test. G, H, Decreased interspike interval (ISI). G, Accumulative curve for the probability distribution of ISI, p < 0.0001, Kolmogorov–Smirnov test. H, DAT-Cre:Td (440.3 ± 2.0 ms) versus DAT-Cul3f/+:Td (346.5 ± 2.4 ms), p < 0.0001, U = 1637985; Mann Whitney test. n = 2472 events, 4 mice for DAT-Cre:Td group; n = 2761 events, 4 mice for DAT-Cul3f/+:Td group. Data are mean ± SEM. **p < 0.01. ***p < 0.001.