Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 6;43(36):6249–6267. doi: 10.1523/JNEUROSCI.0247-23.2023

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 the authors

SfN exclusive license.

PMC Copyright notice

Figure 7. — Increased DA signaling in DAT-Cul3^f/+ mice. A, Schematic diagram represents projections of VTA DA neurons (in light green) and SNc DA neurons (in dark green). Red inset represents NAc, showing that this brain region was collected and subjected to experiment in B. dStr, dorsal striatum. B, Reduced levels of pAkr Thr308 and pTH Ser40 in NAc of P60 DAT-Cul3^f/+ mice compared with Cul3^f/f mice. C, Quantification of data in B. n = 3 mice for each genotype; for pAkt, p = 0.0054, t_(2.585) = 8.77; for pTH, p = 0.0382, t_(2.025) = 4.906; for D2DR, p = 0.1404, t_(3.35) = 1.924; unpaired t test. D, Haloperidol attenuated hyperlocomotion in DAT-Cul3^f/+ mice. n = 12 mice for each group; veh-treated Cul3^f/f versus veh-treated DAT-Cul3^f/+, p = 0.0065; haloperidol-treated Cul3^f/f versus haloperidol-treated DAT-Cul3^f/+, p = 0.9986; veh-treated DAT-Cul3^f/+ versus haloperidol-treated DAT-Cul3^f/+, p = 0.0473; F_(3,44) = 4.72; one-way ANOVA followed by Tukey's post hoc test. E, No difference in time spent in the central area of the open field. n = 12 mice for each group; veh-treated Cul3^f/f versus veh-treated DAT-Cul3^f/+, p = 0.9918; haloperidol-treated Cul3^f/f versus haloperidol-treated DAT-Cul3^f/+, p = 0.7333; veh-treated DAT-Cul3^f/+ versus haloperidol-treated DAT-Cul3^f/+, p = 0.9814; F_(3,44) = 0.3802; one-way ANOVA followed by Tukey's post hoc test. F, Haloperidol restored the PPI ratio in DAT-Cul3^f/+ mice at 82 dB. n = 12 mice for each group. For 73 dB, veh-treated Cul3^f/f versus veh-treated DAT-Cul3^f/+, p = 0.9520; haloperidol-treated Cul3^f/f versus haloperidol-treated DAT-Cul3^f/+, p = 0.9711; veh-treated DAT-Cul3^f/+ versus haloperidol-treated DAT-Cul3^f/+, p = 0.9436; F_(3,44) = 0.1611. For 76 dB, veh-treated Cul3^f/f versus veh-treated DAT-Cul3^f/+, p = 0.0447; haloperidol-treated Cul3^f/f versus haloperidol-treated DAT-Cul3^f/+, p = 0.1496; veh-treated DAT-Cul3^f/+ versus haloperidol-treated DAT-Cul3^f/+, p = 0.6500; F_(3,44) = 4.55. For 82 dB, veh-treated Cul3^f/f versus veh-treated DAT-Cul3^f/+, p < 0.001; haloperidol-treated Cul3^f/f versus haloperidol-treated DAT-Cul3^f/+, p = 0.3345; veh-treated DAT-Cul3^f/+ versus haloperidol-treated DAT-Cul3^f/+, p = 0.0130; F_(3,44) = 10.58; one-way ANOVA followed by Tukey's post hoc test. G, Similar acoustic startle response. n = 12 mice for each group; veh-treated Cul3^f/f versus veh-treated DAT-Cul3^f/+, p > 0.9999; haloperidol-treated Cul3^f/f versus haloperidol-treated DAT-Cul3^f/+, p = 0.2531; veh-treated DAT-Cul3^f/+ versus haloperidol-treated DAT-Cul3^f/+, p = 0.9088; F_(3,44) = 1.225; one-way ANOVA followed by Tukey's post hoc test. Data are mean ± SEM. *p < 0.05. **p < 0.01. ***p < 0.001.