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. 2023 Sep 4;28(17):6434. doi: 10.3390/molecules28176434

Table 3.

CB1/CB2 cannabinoid receptor binding affinity for machaeriol, machaeridiol, and their homologs.

Compound Ki (μM) Function References
rCB1 hCB1 rCB2 mCB2 hCB2
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39 (Machaeriol C)		 3.27 - 7.76 - - - [103]
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43 (Machaeriol D)		 1.75 - 1.30 - - - [103]
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165 		0.34 - 0.57 - - - [103]
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166 		>1000 - 0.040 - - CB2 selective agonists [103]
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106 (Machaeridiol A)		 >1000 - 1.77 - - CB2 selective agonists [103]
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167 (Machaeridiol B)		 >1000 - 2.18 - - CB2 selective agonists [103]
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168 (Machaeridiol C)		 >1000 - 1.11 - - CB2 selective agonists [103]