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A) Generalized 3D orofacial mesenchyme/epithelia interface B) Cross section of CAD model of the device, flanking microchannels (mc) can be seen on either side of the microtissue well (mt). Mesenchyme/ECM and epithelial cells are illustrated on the cross section to show the function of the device. C) Devices (20) machined into a standard 96 well plate, perimeter channels facilitate bonding. D) Single device as viewed from the bottom of the plate integrates 3 wells.
