Figure 2.

Phase 1 cued fear conditioning in female and male mice, collapsed across swim condition. Female (A-E) wildtypes are represented by teal solid lines, and female heterozygotes are represented by blue dashed lines. Male (F-J) wildtypes are represented by orange solid lines, and male heterozygotes are represented by yellow dashed lines. Fear conditioning commenced 4 weeks prior to swim stress exposure for Phase 1. Mice were trained on Day 0 in Context A, then two days later (Day 2), mice were placed in Context B for cued fear expression testing as well as cued fear extinction training. Two days thereafter, mice underwent the identical procedure for the purposes of testing extinction retention (Day 4; C,H) One day later (Day 5), mice were placed in Context A, and were tested for context fear expression (D,I) followed immediately by testing cued fear renewal (E,J). Data are percent time spent freezing for each 30 s period indicated. Data are graphed as mean ± 95% confidence interval. *p=0.027, *p=0.042, *p=0.016 (left to right, panel B); *p=0.021 (panel F); **p=0.002 (panel B); indicate difference between heterozygous and wildtype within same sex at the indicated timepoint.