Figure 3.

Phase 1 context fear conditioning in female and male mice, collapsed across swim condition. Female (A-B) wildtypes are represented by teal solid lines, and female heterozygotes are represented by blue dashed lines. Male (C-D) wildtypes are represented by orange solid lines, and male heterozygotes are represented by yellow dashed lines. Fear conditioning commenced 4 weeks prior to swim stress exposure for Phase 1. Mice were trained on Day 0 in Context A (A,C). Two days later (Day 2), mice were placed back in Context A to test for context fear expression (B,D). Data are percent time spent freezing for each 30 s period following the foot shock (A,C), or every 30 s of testing (B,D). Data are graphed as mean ± 95% confidence interval. *p=0.039 indicates difference between heterozygous and wildtype within same sex at the indicated timepoint.