Figure 7.

Phase 2 context fear conditioning in male mice, separated by swim condition. Male wildtypes are represented by orange solid lines, and male heterozygotes are represented by yellow dashed lines. Fear conditioning occurred 4 weeks after swim stress exposure for Phase 2. Mice were trained on Day 0 in Context A (A,C). Two days later (Day 2), mice were placed back in Context A to test for context fear expression (B,D). Data are percent time spent freezing for each 30 s period following the foot shock (A,C), or every 30 s of testing (B,D). Data are graphed as mean ± 95% confidence interval. *p=0.034 (panel B); *p=0.048, *p=0.013 (left to right, panel D); **p=0.004 (panel D); indicate difference between heterozygous and wildtype within same sex at the indicated timepoint. ^✣p=0.030, ^✣p=0.035, ^✣p=0.011 (left to right, panel D); indicate difference between no swim and swim conditions within same sex and genotype (indicated by color; black for wildtype, grey for heterozygous) at the indicated timepoint.