Figure 2.

Mouse model of GI colonization with K. pneumoniae. (A) Schematic of the in vivo model. Mice were administered 5 days of 350 mg/kg intraperitoneal vancomycin injections before orogastric gavage with 10⁸ CFU K. pneumoniae. Fecal samples were collected after gavage and CFU enumerated. (B) Fecal burden of CRE-166 following gavage into male (square) or female (circle) mice with (red) or without (black) vancomycin treatment prior to gavage. n = 5 for each group. (C) Fecal burdens of strains CRE-166, KPN46, and Z4160 in mouse model of GI colonization. n = 10 for each group. Line indicates median. Limit of detection was 10² CFU/g feces, denoted by a dotted line.