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[Preprint]. 2023 Aug 30:2023.08.29.555158. [Version 1] doi: 10.1101/2023.08.29.555158

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Extended Data Figure 8: — (a) Cryo-EM density and model of CDPPB-bound mGlu5 Intermediate 1b in a nanodisc. Also shown is the density for the two bound CDPPB, one in each TM domain.

(b) Comparison of the allosteric binding pocket in Apo (PDB:6N52, grey) and CDPPB-bound mGlu5 (dark blue), shows changes in TM5 (N747^5.47) and TM6 (W785^6.50) to accommodate CDPPB (slate).

(c) Overlay of CDPPB from Intermediate 1b (dark blue) and Intermediate 3a structures showing minimal changes in the conformation of TM5 and TM6.

(d) Residues that interact with CDPPB only in Intermediate 3a are shown in green (T781^6.46 and C782^6.47) and those that interact with CDPPB only in Intermediate 1b are shown in blue (I751^5.51).