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[Preprint]. 2023 Aug 29:2023.08.28.555225. [Version 1] doi: 10.1101/2023.08.28.555225

Figure 2. Study Overview.

Figure 2.

(A) Experimental design of the spike-in experiment, in which a bovine plasma proteome is spiked into a human plasma proteome at seven different ratios. (B) Proteograph workflow overview which includes protein corona formation, proteins denaturation, reduction, alkylation, protein digestion, and peptide desalting on the Proteograph SP100 automation instrument. Peptides are quantified, dried, and resuspended before injection onto an LC-MS system.