Skip to main content
[Preprint]. 2023 Sep 1:2023.09.01.555937. [Version 1] doi: 10.1101/2023.09.01.555937

Figure 3. CG-MD simulations identify protein insertase complexes as lipid scramblases.

Figure 3.

a. All members of the Oxa1 family of insertases have in silico lipid scrambling activity in their monomeric form. Left: 3D structure of selected members of the Oxa1 family. Right: In silico lipid scrambling quantification. The negative control EcGlpG is shown as reference. b. Mitochondrial insertase complexes have in silico lipid scrambling activity. Left: 3D structure of selected mitochondrial insertase complexes. Right: In silico lipid scrambling quantification. c. ER insertase complexes have in silico lipid scrambling activity. Left: 3D structure of selected ER insertase complexes. Right: In silico lipid scrambling quantification. AlphaFold structures are denoted by the * symbol, number of proteins in the complex is in parenthesis.